Postgraduate Course: High Throughput Drug Discovery (PGBI11077)

Course Outline
School	School of Biological Sciences	College	College of Science and Engineering
Credit level (Normal year taken)	SCQF Level 11 (Postgraduate)	Availability	Not available to visiting students
SCQF Credits	10	ECTS Credits	5
Summary	Online Distance Learning Course The original focus of High throughput screening in drug discovery was on automating assay techniques so that large libraries of molecules could be screened against disease relevant assays. Over time, however, it has developed to include combinatorial synthesis techniques and the design of combinatorial screening libraries. The ultimate aim in this area is to reduce the synthesis and screening costs per compound allowing routine screening of large custom libraries against a wide array of assays.
Course description	Not entered

Entry Requirements (not applicable to Visiting Students)
Pre-requisites		Co-requisites
Prohibited Combinations		Other requirements	None

Course Delivery Information

Academic year 2015/16, Not available to visiting students (SS1)		Quota: None
Course Start	Semester 2
Course Start Date	11/01/2016
Timetable	Timetable
Learning and Teaching activities (Further Info)	Total Hours: 100 ( Online Activities 20, Programme Level Learning and Teaching Hours 2, Directed Learning and Independent Learning Hours 78 )
Assessment (Further Info)	Written Exam 0 %, Coursework 100 %, Practical Exam 0 %
Additional Information (Assessment)	50 % group assessment (including maximum 20% variation for Peer Assessment of contribution) 50 % electronic portfolio comprising learning log and contribution to Skills Profile
Feedback	Not entered
No Exam Information

Learning Outcomes
At the end of this course students should be able to: ż Understand the basics of assay design for use in large scale multiwell robotic screening environments ż Be aware of the issues of reproducibility and false positive/negative signal generation in these types of assay platforms. ż Describe the principles of combinatorial chemistry as applied to the drug discovery process. ż Connect the use of computational chemistry techniques to the design of targeted libraries for drug discovery. ż Be aware of the current developments in solid phase combinatorial chemistry and the impact of single synthesis bead assay techniques.