Postgraduate Course: Protein Structure Determination (PGBI11021)

Course Outline
School	School of Biological Sciences	College	College of Science and Engineering
Credit level (Normal year taken)	SCQF Level 11 (Postgraduate)	Availability	Not available to visiting students
SCQF Credits	10	ECTS Credits	5
Summary	This course will deal with aspects of protein structure determination using multiple techniques including protein crystallography, nuclear magnetic resonance and electron microscopy. In addition lectures showing how multiple techniques can be combined and on developing approaches to structural elucidation will be given.
Course description	Not entered

Entry Requirements (not applicable to Visiting Students)
Pre-requisites		Co-requisites
Prohibited Combinations		Other requirements	One year of University level Chemistry or Biochemistry. A knowledge of elementary Physics would be an advantage.
Additional Costs	None

Course Delivery Information

Academic year 2017/18, Not available to visiting students (SS1)		Quota: None
Course Start	Semester 2
Timetable	Timetable
Learning and Teaching activities (Further Info)	Total Hours: 100 ( Lecture Hours 30, Formative Assessment Hours 2, Summative Assessment Hours 9, Programme Level Learning and Teaching Hours 2, Directed Learning and Independent Learning Hours 57 )
Assessment (Further Info)	Written Exam 0 %, Coursework 100 %, Practical Exam 0 %
Additional Information (Assessment)	1. Class Test (40%) 2. Essay (40%) 3. 10 minute presentation (20%)
Feedback	Not entered
No Exam Information

Learning Outcomes
On completion of this course, the student will be able to: Describe the major techniques used for protein structure determination, and in more detail the use of X-Ray diffraction and Nuclear Magnetic resonance in macromolecular structural determination Understand methods of crystal preparation and X-ray data collection, X-ray data reduction, methods for phase determination, electron density map calculation and interpretation. Summarise methods for peak assignment and distance constraint determination in NMR. Give an overview of sample preparation and data collection in Electron Microscopy.