Postgraduate Course: Molecular Modelling and Database Mining (PGBI11023)
Course Outline
| School | School of Biological Sciences |
College | College of Science and Engineering |
| Course type | Standard |
Availability | Available to all students |
| Credit level (Normal year taken) | SCQF Level 11 (Postgraduate) |
Credits | 10 |
| Home subject area | Postgraduate |
Other subject area | None |
| Course website |
None |
Taught in Gaelic? | No |
| Course description | This module will expose the student to the computational methods involved in structure-based drug design. The student will work on a small project carry out the different steps with a high degree of independence. Supervision will be provided on an introductory basis as well as ad hoc. |
Information for Visiting Students
| Pre-requisites | None |
| Displayed in Visiting Students Prospectus? | Yes |
Course Delivery Information
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| Delivery period: 2012/13 Semester 1, Available to all students (SV1)
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WebCT enabled: Yes |
Quota: None |
| Location |
Activity |
Description |
Weeks |
Monday |
Tuesday |
Wednesday |
Thursday |
Friday |
| No Classes have been defined for this Course |
| First Class |
First class information not currently available |
| No Exam Information |
Summary of Intended Learning Outcomes
Overall: a working knowledge of the software and approaches in current use for protein modelling and structure-based drug design.
Specifically:
1. BLAST, AA alignment, PDB, PFAM,
Given a protein aa sequence, search for homologous proteins. Identify available crystal structures. Secondary structure prediction.
2. Homology modelling
Generate a homology model using suitable software (Modeller, etc).
3. Database mining with LIDAEUS
Search for suitable compounds to bind in the active site by means of virtual screening.
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Assessment Information
| Computer-based examination at the end of the course (December week 12 or 13) |
Special Arrangements
| None |
Additional Information
| Academic description |
Not entered |
| Syllabus |
Not entered |
| Transferable skills |
Not entered |
| Reading list |
Not entered |
| Study Abroad |
Not entered |
| Study Pattern |
Not entered |
| Keywords | MMDB |
Contacts
| Course organiser | Dr Paul Taylor
Tel: (0131 6)50 7058
Email: |
Course secretary | Miss Vicky Mactaggart
Tel: (0131 6)51 7052
Email: |
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