Postgraduate Course: NMR - theory and application (CHEM10064)

Course Outline
School	School of Chemistry	College	College of Science and Engineering
Credit level (Normal year taken)	SCQF Level 10 (Postgraduate)	Availability	Not available to visiting students
SCQF Credits	10	ECTS Credits	5
Summary	NMR spectroscopy is one of the fundamental analytical techniques of a modern analytical laboratory with widespread applicability. It is an invaluable tool for the identification of structures of organic or inorganic molecules. NMR is a non-destructive, non-invasive and quantitative technique, covering many nuclei. NMR spectroscopy has developed well beyond using simple one-dimensional experiments. Multidimensional experiments have dramatically increased the information content of NMR spectra enabling its application to studies of complex molecules, including biomolecules and complex mixtures. The technique excels at following conformational changes, intermolecular interactions, reaction kinetics and physical properties of molecules. The breadth of NMR experiments available led to its dissemination into many disciplines relevant to industry, such as drug discovery, medical diagnostics, food and drink, or environmental monitoring. While most applications discussed in this course involve solution state NMR, solid state NMR will be introduced focusing on application in the drug discovery process. This course will provide the required theory, practical experience in acquisition and interpretation of spectra across a wide range of scientific disciplines.
Course description	The course will consist of a mixture of theory-based lectures, tutorials, instrument/software skill sessions and practicals. The lectures and tutorials will cover the following topics: - Fundamentals of NMR spectroscopy, FT NMR, relaxation times, chemical shifts and coupling constants, number of signals, chemical and magnetic equivalence. - Interpretation of 1D NMR data - 2D NMR, homonculear and heteronuclear experiments - Interpretation of 2D NMR data - Chemical exchange, DOSY, selective excitation - Solid state NMR - Biomolecular NMR ¿ biomolecular interactions and NMR structure determination of biomolecules - Paramagnetic NMR, nuclei other than 1H, metabolomics, mixtures, chemometrics

Entry Requirements (not applicable to Visiting Students)
Pre-requisites		Co-requisites
Prohibited Combinations		Other requirements	None

Course Delivery Information

Academic year 2022/23, Not available to visiting students (SS1)		Quota: None
Course Start	Semester 1
Timetable	Timetable
Learning and Teaching activities (Further Info)	Total Hours: 100 ( Lecture Hours 12, Seminar/Tutorial Hours 18, Summative Assessment Hours 2, Revision Session Hours 2, Programme Level Learning and Teaching Hours 2, Directed Learning and Independent Learning Hours 64 )
Assessment (Further Info)	Written Exam 50 %, Coursework 50 %, Practical Exam 0 %
Additional Information (Assessment)	50% Written Exam 50% Coursework/Practical
Feedback	Not entered
No Exam Information

Learning Outcomes
On completion of this course, the student will be able to: Describe operation of a modern NMR laboratory Describe and apply the basic theory of NMR spectroscopy from simple to more advanced NMR experiments Acquire solution and solid-state NMR spectra: from sample preparation, selection of appropriate experiments and setting acquisition parameters Process acquired NMR data using software to prepare data for interpretation. Assign and interpret NMR spectra to elucidate the structures and properties of molecules