Postgraduate Course: Practical Systems Biology (PGBI11089)
Course Outline
| School | School of Biological Sciences |
College | College of Science and Engineering |
| Credit level (Normal year taken) | SCQF Level 11 (Postgraduate) |
Availability | Available to all students |
| SCQF Credits | 20 |
ECTS Credits | 10 |
| Summary | Molecular biology is being transformed by the recent invention of new technologies, particularly in genome sequencing and single-cell assays, and future research biologists will be expected to be as familiar with the computer as with the pipette. Systems biology is now a generic term to describe such quantitative approaches, particularly in cell and molecular biology. Given that we know the sequence of all the genes in many organisms, the challenge is to understand how these genes interact and, functioning together as a system, produce the remarkable behaviours we associate with life. |
| Course description |
Week 1 Lectures 1 & 2: "What is systems biology?"
The general systems approach with examples. Why a systems approach is important for molecular and cellular biology.
Weeks 2-3 Lectures 3-6: "Fundamentals of modelling biochemical networks"
Mathematical modelling of biochemical reactions, the law of mass action, and a discussion on ultrasensitivity, cooperativity, and Hill numbers.
Weeks 4-5 Lectures 7-10: "Modelling gene expression"
Modelling the rate of transcription for genes controlled by activators and repressors.
Week 6 Lecture 11 & 12: "Sensitivity and metabolic control analysis"
Enzyme kinetics, definitions of sensitivity, and metabolic control analysis to determine metabolic fluxes in engineered systems.
Weeks 7-8 Lectures 13-16: "Positive feedback and genetic switches"
Positive feedback and MAP kinase cascades, bifurcations and hysteresis, cellular memory and bistable genetic networks.
Weeks 9-11 Lectures 17 -22: "Negative feedback and oscillations"
Circadian rhythms, the Tyson model of the circadian clock in the fruit fly, relaxation oscillations, and oscillations through positive and negative feedback.
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Entry Requirements (not applicable to Visiting Students)
| Pre-requisites |
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Co-requisites | |
| Prohibited Combinations | |
Other requirements | None |
Information for Visiting Students
| Pre-requisites | None |
| High Demand Course? |
Yes |
Course Delivery Information
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| Academic year 2017/18, Not available to visiting students (SS1)
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Quota: 46 |
| Course Start |
Semester 1 |
Timetable |
Timetable |
| Learning and Teaching activities (Further Info) |
Total Hours:
200
(
Lecture Hours 22,
Seminar/Tutorial Hours 8,
Programme Level Learning and Teaching Hours 4,
Directed Learning and Independent Learning Hours
166 )
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| Assessment (Further Info) |
Written Exam
0 %,
Coursework
100 %,
Practical Exam
0 %
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| Additional Information (Assessment) |
Two in-course assignments (25% each) and a research project (50%).
The assignments will involve working through a step-by-step computational analysis of a model of a biological system. |
| Feedback |
Not entered |
| No Exam Information |
Learning Outcomes
On completion of this course, the student will be able to:
- explain how interactions between genes can generate some of the behaviour we see in cells
- predict the different behaviours expected of dynamical systems and know how to biochemically 'code' for some of these behaviours
- formulate a mathematical model of a biological system
- generate different hypotheses on the function of a biological system
- perform basic programming and run computer simulations, and use simulation as a tool to help decide between different biological hypotheses
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Reading List
An introduction to Systems Biology, U Alon (Chapman & Hall, 2006)
A Student's Guide to Python for Physical Modelling, JM Kinder & P Nelson (Princeton, 2015)
Primer on Python for Scientific Programming, HP Langtangen (Springer, 2009). Available online.
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Additional Information
| Graduate Attributes and Skills |
Not entered |
| Keywords | PracSystBiol |
Contacts
| Course organiser | Prof Peter Swain
Tel: (0131 6)50 5451
Email: |
Course secretary | Miss Emma Currie
Tel: (0131 6)50 5988
Email: |
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