Postgraduate Course: Modelling Metabolic Pathways (PGBI11080)

Course Outline
School	School of Biological Sciences	College	College of Science and Engineering
Credit level (Normal year taken)	SCQF Level 11 (Postgraduate)
Course type	Online Distance Learning	Availability	Not available to visiting students
SCQF Credits	10	ECTS Credits	5
Summary	Online Distance Learning Course All cells rely on a complex interacting network of numerous metabolic pathways. Each pathway in turn requires the concerted and well-regulated action of a team of enzymes. These pathways with their component enzymes frequently make attractive drug targets. Metabolic pathways in the parasitic protist Trypanosoma brucei (the causative agent of African sleeping sickness) will be used to illustrate how a combination of biochemical, genetic, control analysis and computer simulation approaches can be used to obtain useful working models of these pathways.
Course description	Not entered

Entry Requirements (not applicable to Visiting Students)
Pre-requisites		Co-requisites
Prohibited Combinations		Other requirements	None

Course Delivery Information

Academic year 2017/18, Not available to visiting students (SS1)		Quota: None
Course Start	Semester 2
Course Start Date	21/05/2018
Timetable	Timetable
Learning and Teaching activities (Further Info)	Total Hours: 100 ( Online Activities 20, Programme Level Learning and Teaching Hours 2, Directed Learning and Independent Learning Hours 78 )
Assessment (Further Info)	Written Exam 0 %, Coursework 100 %, Practical Exam 0 %
Additional Information (Assessment)	50 % group assessment (including maximum 20% variation for Peer Assessment of contribution) 50 % electronic portfolio comprising learning log and contribution to Skills Profile
Feedback	Not entered
No Exam Information

Learning Outcomes
On completion of this course, the student will be able to: Appreciate the variability of metabolic status during different life stages of an organism. Determine control strengths of individual components of metabolic pathways under defined conditions. Model how changes in metabolite concentrations will affect flux through a pathway. Explain why particular enzyme components of a pathway may be better drug targets than others. Devise strategies to explore possible synergy effects when more than one enzyme is inhibited.