Postgraduate Course: Measuring Drug Binding (PGBI11071)
Course Outline
| School | School of Biological Sciences |
College | College of Science and Engineering |
| Course type | Standard |
Availability | Not available to visiting students |
| Credit level (Normal year taken) | SCQF Level 11 (Postgraduate) |
Credits | 10 |
| Home subject area | Postgraduate |
Other subject area | None |
| Course website |
None |
Taught in Gaelic? | No |
| Course description | **Online Distance Learning Course**
A core competency in Drug Discovery is to appreciate how to measure drug binding quantitatively, in order to assess derivatives of a &«lead&ª compound that bind more tightly. There are common pitfalls in the interpretation of these numbers, which are inadequately appreciated by many. The course is designed to introduce students to concepts and nomenclature in quantitating drug binding. A common technique involving fluorescence quenching will be used for illustration. Students will fit experimental data using a variety of models and use statistical techniques to distinguish between them. Concepts of over- and under-fitting data, and correlation of parameters will be illustrated, as well as confounding artefacts that affect biophysical techniques. |
Entry Requirements (not applicable to Visiting Students)
| Pre-requisites |
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Co-requisites | |
| Prohibited Combinations | |
Other requirements | None |
| Additional Costs | None |
Course Delivery Information
| Not being delivered |
Summary of Intended Learning Outcomes
At the end of this course students should be able to:
&· Demonstrate advanced knowledge of concepts applied to measuring drug binding;
&· Acquire the ability to use common software to fit experimental data and to extend this into unknown situations;
&· Show an appreciation of under- and over-fitting experimental data and be able to use statistical methods to demonstrate either;
&· Show awareness in the literature of common pitfalls in measuring drug binding ;
&· Have acquired a critical faculty regarding potential artifacts in biophysical techniques.
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Assessment Information
50% = Group Assessment (including maximum 20% variation for Peer Assessment of contribution)
50% = Electronic Portfolio (comprising of learning log and contribution to skills profile)
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Special Arrangements
| None |
Additional Information
| Academic description |
Not entered |
| Syllabus |
Not entered |
| Transferable skills |
Not entered |
| Reading list |
Not entered |
| Study Abroad |
Not entered |
| Study Pattern |
Not entered |
| Keywords | MDB |
Contacts
| Course organiser | Dr Paul Mclaughlin
Tel: (0131 6)50 7060
Email: |
Course secretary | Miss Vicky Mactaggart
Tel: (0131 6)51 7052
Email: |
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