Postgraduate Course: Structure Determination of Drug Targets (PGBI11070)
Course Outline
| School | School of Biological Sciences |
College | College of Science and Engineering |
| Course type | Standard |
Availability | Not available to visiting students |
| Credit level (Normal year taken) | SCQF Level 11 (Postgraduate) |
Credits | 10 |
| Home subject area | Postgraduate |
Other subject area | None |
| Course website |
None |
Taught in Gaelic? | No |
| Course description | **Online Distance Learning Course**
In Drug Discovery that has a rationale basis a three-dimensional structure of the target is a necessity. Students need an appreciation of X-ray crystallography to be able to evaluate critically their credence in crystallographic models used in this work.
This course will lead students through the process, illustrating the criteria for reliable models and the sometimes subtle hints that others are wrong in detail, while a few are grossly wrong through naivety or fraud.
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Entry Requirements (not applicable to Visiting Students)
| Pre-requisites |
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Co-requisites | |
| Prohibited Combinations | |
Other requirements | None |
| Additional Costs | None |
Course Delivery Information
| Not being delivered |
Summary of Intended Learning Outcomes
At the end of this course students should be able to:
&· Read a x-ray crystallography paper with an appreciation of the methods and the reliability of the model;
&· Take an unknown model and test its reliability using software that tests its probity;
&· Acquire advanced knowledge of correct protein stereochemistry as a measure of reliability;
&· Appreciate the concept of phase bias in electron density maps;
&· Demonstrate a knowledge of what can be expected of a crystallographic model determined at any particular resolution.
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Assessment Information
50% = Group Assessment (including maximum 20% variation for Peer Assessment of contribution)
50% = Electronic Portfolio (comprising of learning log and contribution to skills profile)
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Special Arrangements
| None |
Additional Information
| Academic description |
Not entered |
| Syllabus |
Not entered |
| Transferable skills |
Not entered |
| Reading list |
Not entered |
| Study Abroad |
Not entered |
| Study Pattern |
Not entered |
| Keywords | SDDT |
Contacts
| Course organiser | Prof Lindsay Sawyer
Tel: (0131 6)50 7062
Email: |
Course secretary | Miss Vicky Mactaggart
Tel: (0131 6)51 7052
Email: |
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