Undergraduate Course: Mammalian Transgenic Technology and Regenerative Medicine (MLBI10020)
Course Outline
| School | School of Biological Sciences |
College | College of Science and Engineering |
| Course type | Standard |
Availability | Available to all students |
| Credit level (Normal year taken) | SCQF Level 10 (Year 4 Undergraduate) |
Credits | 10 |
| Home subject area | Molecular Biology |
Other subject area | None |
| Course website |
None |
Taught in Gaelic? | No |
| Course description | The course will cover the technologies and principles involved in the generation of genetically modified mammalian organisms, and explore their use in fundamental and applied research, with special emphasis on stem cell biology, development and genetic modeling of human disease. Specific topics will include use of homologous and site-specific DNA recombination in generation of normal and BAC transgenes, embryonic stem cell-based gene targeting and methods for modification of the mammalian germline. In addition, the generation and use of human and mouse induced pluripotent stem cells, their modification and directed differentiation, and the use of derived cells in cell therapies, disease modeling, pharmacology and basic research will be covered. Sessions will include student-led discussion of relevant literature. |
Entry Requirements (not applicable to Visiting Students)
| Pre-requisites |
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Co-requisites | |
| Prohibited Combinations | |
Other requirements | None |
| Additional Costs | None |
Information for Visiting Students
| Pre-requisites | None |
| Displayed in Visiting Students Prospectus? | No |
Course Delivery Information
| Not being delivered |
Summary of Intended Learning Outcomes
| Students will after the course: (1) be familiar with the molecular technologies used to generate and regulate mammalian transgenes, including recombinases, gene regulatory systems and the use of protein fusions in protein activity control; (2) understand the biological background for and use of injection-based and ES cell-based genomic modification, and their respective advantages and disadvantages; (3) be familiar with the use of genetic modification in the modeling of human diseases, including cancer, CNS disorders and congenital monogenic diseases; (4) have knowlege of the biological basis for ES cell pluripotentcy and the technologies involved in generation of induced pluripotent stem (iPS) cells; (5) know the use of ES and iPS cells in disease modeling, pharmacological research and cell therapy; (6) be able to comprehend and present scientific literature in the areas covered. |
Assessment Information
| Assessment will be through open book exam (6-9 questions assessed/student, 2hr duration). |
Special Arrangements
| None |
Additional Information
| Academic description |
Not entered |
| Syllabus |
Not entered |
| Transferable skills |
Not entered |
| Reading list |
Not entered |
| Study Abroad |
Not entered |
| Study Pattern |
Not entered |
| Keywords | MLBI-MTTRMed |
Contacts
| Course organiser | Prof Claus Nerlov
Tel: (0131 6)50 5853
Email: |
Course secretary | Miss Donna Wright
Tel: (0131 6)51 7051
Email: |
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