Undergraduate Course: Drug Discovery (BICH10016)
Course Outline
| School | School of Biological Sciences |
College | College of Science and Engineering |
| Course type | Standard |
Availability | Available to all students |
| Credit level (Normal year taken) | SCQF Level 10 (Year 4 Undergraduate) |
Credits | 10 |
| Home subject area | Biochemistry |
Other subject area | None |
| Course website |
None |
Taught in Gaelic? | No |
| Course description | Pharmaceutical drugs have traditionally developed from herbal remedies or from the random screening for beneficial effects of natural or synthetic chemicals. We now have a detailed understanding of many diseases at a molecular level. The aim of this course is to explain how we can use the structure and function of proteins involved in a disease to design new potential drug molecules. There are now over ten examples of drugs which are now in the clinic which have been devised and developed using this so called 'Rational Drug Design' approach. Some better known examples will be discussed including inhibitors for HIV-protease (AIDS), neuraminidase (influenza), thrombin (thrombosis) and collagenase (degenerative diseases). We will also look at some of the computer-graphics methods used to design and model potential inhibitor ligands into the binding pockets of target proteins. |
Entry Requirements (not applicable to Visiting Students)
| Pre-requisites |
|
Co-requisites | |
| Prohibited Combinations | |
Other requirements | None |
| Additional Costs | Notepads |
Information for Visiting Students
| Pre-requisites | None |
| Displayed in Visiting Students Prospectus? | Yes |
Course Delivery Information
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| Delivery period: 2012/13 Block 3 (Sem 2), Available to all students (SV1)
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WebCT enabled: Yes |
Quota: None |
| Location |
Activity |
Description |
Weeks |
Monday |
Tuesday |
Wednesday |
Thursday |
Friday |
| King's Buildings | Lecture | | 1-6 | | | | 14:00 - 15:50 | | | King's Buildings | Lecture | | 1-6 | | 14:00 - 15:50 | | | |
| First Class |
First class information not currently available |
| No Exam Information |
Summary of Intended Learning Outcomes
- Increased understanding of Biological processes.
- Overview of the methods used in structure-based drug design
- An appreciation of the role molecular structure and biochemical mechanisms play in the design of new drug modules |
Assessment Information
- A 5 page report outlining a plan for lead discovery for a given protein drug target (70%)
- A presentation handout of up to 12 slides (20%)
- A written evaluation of other presentation hand-outs (10%) |
Special Arrangements
| None |
Additional Information
| Academic description |
Not entered |
| Syllabus |
Not entered |
| Transferable skills |
Not entered |
| Reading list |
Not entered |
| Study Abroad |
Not entered |
| Study Pattern |
Not entered |
| Keywords | BIOCHEMDrugDisc |
Contacts
| Course organiser | Prof Malcolm Walkinshaw
Tel: (0131 6)50 3719
Email: |
Course secretary | Mr Fraser Bryden
Tel: (0131 6)50 8637
Email: |
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