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Medicinal Chemistry Level 11 (U01234)

? Credit Points : 20 ? SCQF Level : 11 ? Acronym : CHE-4-MedChem11

A lecture course covering instruction in both the theory and application of medicinal chemistry. The course comprises individual lectures courses on: Metals in Medicine, Nucleic Acids, Medicinal Chemistry and Industrial Medicinal Chemistry. Either the Level 10 or Level 11 version of this course (as specified in the degree programme tables) is a compulsory requirement for Year 4/5 students on degrees in Medicinal and Biological Chemistry, but can be taken by Year 4/5 students on any Chemistry degree programme.

Entry Requirements

? Pre-requisites : Chemistry 3A (CHE-3-A) and Chemistry 3B (CHE-3-B) and Chemistry 3P Practical and Transferable Skills (CHE-3-Pract) at a weighted average at or above Grade C at the first attempt (including Chemistry 3A (CHE-3-A) and Chemistry 3B (CHE-3-B) at a weighted average at or above Grade D), and Mathematics qualifications of at least 20 credits to level Applicable Mathematics 1 and Mathematical Methods 1; or with the permission of Head of School.

? Prohibited combinations : Medicinal Chemistry Level 10 (CHE-4-MedChem10).

Subject Areas

Home subject area

Chemistry, (School of Chemistry, Schedule L)

Delivery Information

? Normal year taken : 4th year

? Delivery Period : Semester 2 (Blocks 3-4)

? Contact Teaching Time : 3 hour(s) per week for 10 weeks

First Class Information

Date	Start	End	Room	Area	Additional Information
08/01/2008	11:10	12:00	Lecture Theatre 100, Joseph Black Building	KB

All of the following classes

Type	Day	Start	End	Area
Lecture	Tuesday	11:10	12:00	KB
Lecture	Wednesday	11:10	12:00	KB
Lecture	Friday	11:10	12:00	KB

? Additional Class Information : 30 hours lectures + 6 hours tutorials, at times arranged.

Summary of Intended Learning Outcomes

At the end of this course students will be able to:
- describe the biomedical periodic table and the uses of metals in medicine
- show an understanding of the biological significance of RNA and DNA
- show a basic understanding of oligonucleotide chemistry and how it relates to therapeutic and diagnostic applications
- show understanding of rational approaches towards the design of important drugs and the biological implications of such therapeutic agents including the use of enzymes to inhibit protein processing as a concept for the design of new pharmaceuticals
- describe common routes of administration of drugs and drug delivery systems
- describe common metabolic pathways and how they may be exploited in the design of drugs, prodrugs and soft drugs
- describe the basic body functions controlled by hormonal steroids and also how steroids are exploited for non-hormonal uses, particularly neuromuscular blocking agents
- discuss the therapeutic potential for GABAA receptor modulators with particular reference to general anaesthetics including steroids
- discuss the importance of new highspeed technologies for the generation of lead compounds and structure-activity relationships, in particular combinatorial chemistry, high throughput screening and automation
- show understanding of the biological importance of opioids as analgesics
Learning outcomes specific to attainment of a pass at Level 11 include:
- ability to integrate all, or most, of the main areas of the course
- development of original and creative responses to problems and issues within the course
- application of critical analysis, evaluation and synthesis to issues at the forefront of the subject area