Genomics and Pathway Biology I (P02160)

? Credit Points : 40 ? SCQF Level : 11 ? Acronym : MED-P-P01378

Post genomics continues to be a rapidly evolving field. This is particularly true in the mapping and modelling of biological systems using datasets from high throughput genomic, proteomic and imaging experiments. Sophisticated modelling and analytical methods are being developed via an interdisciplinary approach involving biologists, bioinformatics, computational and physical sciences. The mapping and interpretation of biological pathways and networks is critical for a more complete understanding of biological systems relevant to disease and development. In order to achieve this, it is becoming increasingly possible to derive sophisticated biological pathways and networks from high throughput genomic (transcriptomic and RNA interference), proteomic and imaging data.

The course will run in semester 1 and will provide an important new component that will complement and greatly strengthen the current MSc genomics programme run by the GTI.

The course will provide (1) an introduction to the genetic pathways underpinning development, normal function and disease, together with the tools for mapping them formally, (2) seminar presentations and discussion by the students on important papers associated with pathways, and (3) 12-week mini projects on pathways biology which may be either laboratory-based or involve computational work.

Seminars and lectures will be held twice weekly. Topics will include:

- Introductory sessions on pathway mapping and analysis.
- Outline of IT technologies and systems for generating and interpreting biological networks
- Data integration and use of ontologies in pathway and network modelling
- Exploring through seminar work important examples of biological networks, including:
- Viral-host interactions
- The interferon regulatory network
- Modelling of the tumour necrosis factor network
- Systems biology of the macrophage
- Modelling of tissue specific gene expression in disease and development

Entry Requirements

none

Subject Areas

Home subject area

Life Sciences, (Medicine, Schedule R)

Delivery Information

? Normal year taken : Postgraduate

? Delivery Period : Semester 1 (Blocks 1-2)

Summary of Intended Learning Outcomes

- provide students with thorough and specific preparation for 3 year PhD training in the life sciences;
- award an MSc by Research en route to the PhD;
provide an opportunity, if necessary or desirable, to exit from research training at the end of Year 1 with an Edinburgh Masters or Diploma by Research Degree