Synthetic Organic Chemistry Level 11 (U01247)

? Credit Points : 20 ? SCQF Level : 11 ? Acronym : CHE-4-SynOrg11

A lecture course covering contemporary synthetic methods in organic chemistry, and their application to complex molecule synthesis. The course comprises individual lecture courses on: Reagents for Organic Synthesis, Synthesis of Natural Products, Solid Phase Synthesis, Synthesis of Unnatural Products, Pericyclic Reactions, Organometallics in Synthesis. Either the Level 10 or Level 11 version of this course (as specified in the degree programme tables) is a compulsory requirement for Year 4/5 students on degrees in Chemistry or Medicinal and Biological Chemistry, but can be taken by Year 4/5 students on any Chemistry degree programme.

Entry Requirements

? Pre-requisites : Chemistry 3A (CHE-3-A) and Chemistry 3B (CHE-3-B) and Chemistry 3P Practical and Transferable Skills (CHE-3-Pract) at a weighted average at or above Grade C at the first attempt (including Chemistry 3A (CHE-3-A) and Chemistry 3B (CHE-3-B) at a weighted average at or above Grade D), and Mathematics qualifications of at least 20 credits to level Applicable Mathematics 1 and Mathematical Methods 1; or with the permission of Head of School.

? Prohibited combinations : Synthetic Organic Chemistry Level 10 (CHE-4-SynOrg10).

Subject Areas

Home subject area

Chemistry, (School of Chemistry, Schedule L)

Delivery Information

? Normal year taken : 4th year

? Delivery Period : Semester 1 (Blocks 1-2)

? Contact Teaching Time : 3 hour(s) per week for 10 weeks

First Class Information

Date	Start	End	Room	Area	Additional Information
19/09/2006	09:00	09:50	Lecture Theatre 100, Joseph Black Building	KB

All of the following classes

Type	Day	Start	End	Area
Lecture	Tuesday	09:00	09:50	KB
Lecture	Wednesday	09:00	09:50	KB
Lecture	Friday	09:00	09:50	KB

? Additional Class Information : 30 hours lectures + 6 hours tutorials, at times arranged.

Summary of Intended Learning Outcomes

At the end of this course students will be able to:
- discuss the chemistry and applications of a range of phosphorus, silicon, sulfur and selenium reagents in modern organic synthesis
- compare and contrast the biosynthesis of natural products with their chemical synthesis in the laboratory
- discuss the relative merits of solid phase and solution phase organic synthesis
- understand the role of solid phase organic synthesis in the pharmaceutical industry, particularly with respect to the use of combinatorial chemistry in screening against biological targets
- discuss the synthesis of various functional molecular architectures and the principles behind molecular switches, motors, shuttles and other 'designer' molecules
- apply Frontier Molecular Orbital (FMO) theory to predict the results of electrocyclic, cycloaddition and sigmatropic rearrangement processes
- compare and contrast mechanistic details of common modern synthetic organometallic reactions
- predict the outcome of some simple transition metal catalysed processes and comment on the strategies used by others for the synthesis of more complex targets
Learning outcomes specific to attainment of a pass at Level 11 include:
- ability to integrate all, or most, of the main areas of the course
- development of original and creative responses to problems and issues within the course
- application of critical analysis, evaluation and synthesis to issues at the forefront of the subject area