Chemical Biology Level 10 (U01222)

? Credit Points : 20 ? SCQF Level : 10 ? Acronym : CHE-4-ChemBio10

The course covers the application of organic chemistry methods, theory and mechanism to biological systems. The course also describes methods used to manipulate and study cellular processes. Individual lecture courses comprise: Biocatalysis in Synthesis, Molecular Enzymology, Carbohydrates, Molecular Engineering, and Bioinorganic Chemistry. Either the Level 10 or Level 11 version of this course (as specified in the degree programme tables) is a compulsory requirement for Year 4/5 students on degrees in Medicinal and Biological Chemistry, but can be taken by Year 4/5 students on any Chemistry degree programme.

Entry Requirements

? Pre-requisites : Chemistry 3A (CHE-3-A) and Chemistry 3B (CHE-3-B) at a weighted average at or above Grade D at the first attempt, and Chemistry 3P Practical and Transferable Skills (CHE-3-Pract), and Mathematics qualifications of at least 20 credits to level Applicable Mathematics 1 and Mathematical Methods 1; or with the permission of Head of School.

? Prohibited combinations : Chemical Biology Level 11 (CHE-4-ChemBio11).

Subject Areas

Home subject area

Chemistry, (School of Chemistry, Schedule L)

Delivery Information

? Normal year taken : 4th year

? Delivery Period : Semester 2 (Blocks 3-4)

? Contact Teaching Time : 3 hour(s) per week for 10 weeks

First Class Information

Date	Start	End	Room	Area	Additional Information
09/01/2007	10:00	10:50	Lecture Theatre 100, Joseph Black Building	KB

All of the following classes

Type	Day	Start	End	Area
Lecture	Tuesday	10:00	10:50	KB
Lecture	Wednesday	10:00	10:50	KB
Lecture	Friday	10:00	10:50	KB

? Additional Class Information : 30 hours lectures + 6 hours tutorials, at times arranged.

Summary of Intended Learning Outcomes

At the end of this course students will be able to:
- understand the role played by enzymes in modern asymmetric synthesis
- discuss the range of chemical reactions amenable to biocatalysis
- understand the role of common cofactors such as ATP, NAD, biotin, thiamine and pyridoxal phosphate in enzymatic reactions
- describe synthetic procedures involved in carbohydrate synthesis, and the methods used for carbohydrate structure determination
- understand the potential (and limitations) of genetic techniques in the development of our understanding of cellular pathways and in drug design
- explain the theory which underpins current understanding of protein mediated electron transfer and the physical methods used to determine redox processes occurring in metalloproteins
- provide examples of the variety of chemical reactions catalyzed by metals in enzymes