? Credit Points : 10  ? SCQF Level : 10  ? Acronym : BMS-4-MItypeIII

This elective topic will cover the basic biology of type III secretion systems in key pathogens such as Salmonella, Yersinia, and enterohaemorrhagic Escherichia coli (EHEC). The course will start with information about the different export systems that bacteria have, for example those used to export toxins out of the cell or assemble adhesins onto the bacterial cell surface. The course will then focus on the type III secretion apparatus itself. What is its structure?
How is it assembled? How are proteins for export chosen? How are they actually exported? The course will then look at individual pathogens (as above) and consider the variety of 'effector' proteins that are injected into host cells. How do these proteins act to disable macrophages, prevent inflammation, hinder epithelial cell turnover, force bacterial invasion or allow intimate bacterial binding? The course also aims to provide background information on the molecular techniques used to investigate this exciting biology. This includes how to construct genetic mutations in bacteria, how to construct gene fusions, how to measure gene expression levels, how to identify novel secreted proteins and how to determine protein function. This understanding will be of general value for students wanting to interpret scientific papers analysing the molecular basis of any infectious disease.

? This course is not available to visting students.

? Pre-requisites : Permission of the Curriculum Approval Officer.

Home subject area

Microbiology and Infection (Biomedical Sciences), (School of Biomedical Sciences, Schedule T)

Other subject areas

Microbiology and Infection (Biological Sciences), (School of Biological Sciences, Schedule K)

? Normal year taken : 4th year

? Delivery Period : Semester 1 (Blocks 1-2)

? Contact Teaching Time : 2 hour(s) 45 minutes per week for 11 weeks

First Class Information

Date Start End Room Area Additional Information 21/09/2006 15:00 17:00 Biomedical Seminar Room 5, Medical School, Teviot Place

All of the following classes

Type Day Start End Area Lecture Thursday 14:00 18:00 Central

Increased understanding of biological processes.
Detailed learning outcomes will be provided later.

30% ICA & 70% exam.

Exam times

Diet Diet Month Paper Code Paper Name Length 1ST December 1 - 1 hour(s) 30 minutes

The Course Secretary should be the first point of contact for all enquiries.

Course Secretary

Mrs Patricia Anne Law
Tel : (0131 6)50 3161
Email : Anne.Law@ed.ac.uk

Course Organiser

Dr Simon Talbot
Tel : (0131 6)50 7938
Email : stalbot@ed.ac.uk

School Website : http://www.dbcls.med.ed.ac.uk/

College Website : http://www.mvm.ed.ac.uk/