Physical Chemistry in Action Level 10 (U01235)

? Credit Points : 20 ? SCQF Level : 10 ? Acronym : CHE-4-PCinAct10

A lecture course covering instruction in the theory and application of modern advanced instrumentation techniques to chemistry. The course comprises individual lectures courses on: Mass Spectrometry, Sensors, Microscopy and Imaging, and Biomolecular Systems. The course is suitable for Year 4/5 students on any Chemistry degree programme.

Entry Requirements

? Pre-requisites : Chemistry 3A (CHE-3-A) and Chemistry 3B (CHE-3-B) at a weighted average at or above Grade D at the first attempt, and Chemistry 3P Practical and Transferable Skills (CHE-3-Pract), and Mathematics qualifications of at least 20 credits to level Applicable Mathematics 1 and Mathematical Methods 1. Or CP Symmetry and Structure (CHE-3-CPSymStr) and CP Kinetics and Catalysis (CHE-3-CPKinCat) and CP Molecules and Matter (CHE-3-CPMolMat) and Electromagnetism (PHY-3-ElMag) and Optics (PHY-3-Optics) and Physical Mathematics (PHY-3-PhMath) and Quantum Mechanics (PHY-3-QuantMech) and Statistical Mechanics (PHY-3-StatMech) at a weighted average at or above Grade D, and CP Practical and Transferable Skills (CHE-3-CPPract), and Electronic Methods in Physical Laboratory (PHY-3-ElMeth), and Computational Methods (PHY-3-CompMeth), and Applicable Mathematics 3 (Phys Sci), and Mathematical Methods 3 (Phys Sci), and Foundations of Mathematical Physics 2 (PHY-2-FoMP). Or with permission of Head of School.

? Prohibited combinations : Physical Chemistry in Action Level 11 (CHE-4-PCinAct11).

Subject Areas

Home subject area

Chemistry, (School of Chemistry, Schedule L)

Delivery Information

? Normal year taken : 4th year

? Delivery Period : Semester 2 (Blocks 3-4)

? Contact Teaching Time : 3 hour(s) per week for 10 weeks

First Class Information

Date	Start	End	Room	Area	Additional Information
08/01/2007	14:00	14:50	Lecture Theatre 100, Joseph Black Building	KB

All of the following classes

Type	Day	Start	End	Area
Lecture	Monday	14:00	14:50	KB
Lecture	Thursday	14:00	14:50	KB
Lecture	Friday	14:00	14:50	KB

? Additional Class Information : 30 hours lectures + 6 hours tutorials, at times arranged.

Summary of Intended Learning Outcomes

At the end of this course students will be able to:
- review the principles of different types of ion sources (including MALDI, electrospray ionisation, field and plasma ionisation and desorption), mass analysers (including quadrupole, ion-trap, time-of-flight, ion cyclotron and FT mass analysers), ion detectors and computer-aided data processing in modern mass spectrometry
- discuss novel techniques of mass spectroscopic analysis of proteins in a solvent free environment
- interpret fragmentation patterns, particularly as applied to peptide mass fingerprinting
- describe the essential elements of chemical sensors and rationalise the importance of factors such as sensitivity, selectivity, dynamic range, reproducibility, operating environment and cost
- illustrate examples of the chemical synthesis of specific molecular recognition systems and natural biosensor systems
- understand the physical principles of optical, electron and scanning probe microscopies, including confocal microscopy, scanning near field optical microscopy, electron microscopy, scanning tunnelling microscopy and atomic force microscopy
- illustrate example applications of fluorescence microscopy and imaging and in-situ microscopy studies of surface chemistry and catalysis
- understand thermodynamic and kinetic aspects of protein structure and dynamics
- rationalise the influence of the intracellular environment on the behaviour of macromolecules
- illustrate how modern analytical techniques are used to gain insight into the dynamics of the living cell with particular emphasis on the interactions between protein and DNA