Immunobiology of Malaria (U00726)

? Credit Points : 10 ? SCQF Level : 10 ? Acronym : BIO-4-IMmal

This course is designed to provide an advanced understanding of practical and theoretical consequences of immunological processes triggered by malaria, a leading cause of morbidity and mortality in the tropics. Immune responses can benefit or harm the host, and the course will examine immune mechanisms that can mediate protection as well as pathways responsible for malaria pathology. Topics of lectures and/or discussion sessions will include: An overview of Plasmodia, their biology & the role of sexual reproduction in the generation of antigenic diversity. Animal models of malaria immunity and of pathogenesis. Pathogenesis of human malaria, a spectrum of clinical forms. The dynamics & hypotheses of acquired immunity in humans. Parasite modulation of host responses, immunodepression & interactions with other infections. P. falciparum genome & antigen genes. Development of malaria vaccines. Population genetics & some evolutionary aspects of vaccine deployment

Entry Requirements

? Pre-requisites : Immunology 3m; Genomes & Genomics 3h, Medical Microbiology 3m, Molecular Cell Biology 3m are recommended

Subject Areas

Home subject area

Immunology, (School of Biological Sciences, Schedule K)

Delivery Information

? Normal year taken : 4th year

? Delivery Period : Semester 1 (Blocks 1-2)

? Contact Teaching Time : 2 hour(s) 45 minutes per week for 11 weeks

First Class Information

Date	Start	End	Room	Area	Additional Information
27/09/2006	09:30	12:30	Room 1.0115, Ashworth Labs	KB	Honours Room 1

All of the following classes

Type	Day	Start	End	Area
Lecture	Wednesday	09:00	13:00	KB

Summary of Intended Learning Outcomes

Immunological evaluation and understanding of malaria, arguably the most important parasitic infection of mankind and an outstanding challenge to practical immunology. Transferable skills will be enhanced by presentations and discussions of scientific papers.